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Preimplantation Genetic Diagnosis (PGD)

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Preimplantation genetic test for monogenic disorders (PGT-M)-

PGT-M is a procedure used prior to implantation to help identify genetic defects within embryos created through in vitro fertilization to prevent certain diseases or disorders from being passed on to the child.

How is the PGT-M performed?

Preimplantation genetic diagnosis begins with the normal process of in vitro fertilization that includes egg retrieval and fertilization in a laboratory. Over the next three days the embryo will divide into eight cells.

Preimplantation genetic diagnosis involves the following steps:

  1. First, one or two cells are removed from the embryo.
  2. The cells are then evaluated to determine if the inheritance of a problematic gene is present in the embryo.
  3. Once the PGT-M procedure has been performed and embryos free of genetic problems have been identified, the embryo will be placed back in the uterus, and implantation will be attempted.
  4. Any additional embryos that are free of genetic problems may be frozen for later use while embryos with the problematic gene are destroyed.
Indications for PGT-M?
  • Preimplantation genetic diagnosis can benefit any couple at risk for passing on a genetic disease or condition.
  • Previous child with an inherited disease e.g Thalassemia
What are the benefits of PGT-M?

The following are considered benefits of PGT-M:

  • PGT-M can test for more than 100 different genetic conditions.
  • The procedure is performed before implantation thus allowing the couple to decide if they wish to continue with the pregnancy.
  • The procedure enables couples to pursue biological children who are free from any disease running in the family.

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Preimplantation Genetic Diagnosis (PGD) (1)


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