REPRODUCTIVE DISORDERS – PGT
PREIMPLANTATION GENETIC TESTING
Preimplantation genetic testing is performed before embryo transfer during IVF so that doctors may pick one without a known or suspected gene problem (PGT-A), or one without an abnormal number of chromosomes (PGT-M). The goal of both PGT-A and PGT-M is to increase the chance of selecting a healthy embryo that will develop into a healthy baby.
It is estimated that genetics contribute up to 10% of infertility issues or recurrent pregnancy losses in couples. The risk of finding chromosomal abnormalities grows as the age of the woman increases. Most embryos with an incorrect number of chromosomes fail to implant or miscarry during the first trimester of pregnancy. Genetic testing protocols have the potential to help many of those couples in their quest to have a family. Our comprehensive list of genetic testing services can greatly increase your chances of getting pregnant.
PGT-A (Preimplantation Genetic Testing – Aneuploidy)
PGT-A is genetic testing performed on embryos to identify numerical chromosomal abnormalities or aneuploidy. This test is performed on embryos prior to transfer into the uterus. By analysing all embryos generated in an IVF treatment cycle, those free of chromosomal aneuploidy can be identified for selective transfer. As a result, the pregnancy rates per transfer are increased and the miscarriage rates decreased.
PGT-M (Preimplantation Genetic Testing – Monogenic)
PGT-M involves testing of embryos for specific monogenic disorders like thalassemia, haemophilia and certain types of muscular dystrophy. It helps couples who have a family history or those who have had a child affected with these disorders to have an unaffected child. All embryos formed as a part of an Assisted Reproductive Technology (ART) are tested for this specific monogenic disorder. Only unaffected or career embryos are transferred to have a disease-free child. This can also be combined with PGT-A to further improve success rates.
Why PGT is required?
- For patients with a normal uterus and with normal endometrial thickness (≤6mm), in which no problems are apparent
- For patients with advanced maternal age.
- For patients who have had implantation failure with embryos of good morphological quality (at least 3 failed embryo transfers for women younger than 37 years or 2 failed transfer in women older than 37 years)
- For patients with a positive history of chromosomal aneuploidy or a genetic disorder in the family.